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18 source papers

Original source papers

  1. 2026Frontiers in medicine

    MOTS-c partially protects against skeletal muscle deterioration in C26 cachexia.

    Jamnick NA, Livingston PD, Gammon CJ et al.

  2. 2026 Jun 4Journal of translational medicine

    MOTS-c: How a secreted mitochondrial microprotein may become a potential treatment for inflammatory lung diseases.

    Amado CA, Agüero J, García-Unzueta M et al.

  3. 2025 AugExperimental & molecular medicine

    Mitochondrial-encoded peptide MOTS-c prevents pancreatic islet cell senescence to delay diabetes.

    Kong BS, Lee H, L'Yi S et al.

  4. 2025 Aug 6Clinical and experimental medicine

    Diagnostic relevance of Humanin, GAS5 and miR-21/miR-103 in prostate disease risk stratification.

    Coradduzza D, Cruciani S, Sibono L et al.

  5. 2025Frontiers in physiology

    Mitochondria-derived peptide MOTS-c restores mitochondrial respiration in type 2 diabetic heart.

    Pham T, Taberner A, Hickey A et al.

  6. 2024 Nov 15iScience

    MOTS-c modulates skeletal muscle function by directly binding and activating CK2.

    Kumagai H, Kim SJ, Miller B et al.

  7. 2024 NovAdvanced science (Weinheim, Baden-Wurttemberg, Germany)

    Mitochondrial-Derived Peptide MOTS-c Suppresses Ovarian Cancer Progression by Attenuating USP7-Mediated LARS1 Deubiquitination.

    Yin Y, Li Y, Ma B et al.

  8. 2024Theranostics

    Mitochondria-encoded peptide MOTS-c participates in plasma membrane repair by facilitating the translocation of TRIM72 to membrane.

    Jia H, Zhou LC, Chen YF et al.

  9. 2024 Mar 1American journal of physiology. Endocrinology and metabolism

    Mitochondrial-derived microprotein MOTS-c attenuates immobilization-induced skeletal muscle atrophy by suppressing lipid infiltration.

    Kumagai H, Kim SJ, Miller B et al.

  10. 2024 Jan 5Gut

    Novel function of MOTS-c in mitochondrial remodelling contributes to its antiviral role during HBV infection.

    Lin C, Luo L, Xun Z et al.

  11. 2023Frontiers in endocrinology

    MOTS-c: A promising mitochondrial-derived peptide for therapeutic exploitation.

    Zheng Y, Wei Z, Wang T

  12. 2022 Dec 6Aging

    Circulating levels of MOTS-c in patients with breast cancer treated with metformin.

    Cuyàs E, Verdura S, Martin-Castillo B et al.

  13. 2022 Jul 21Journal of clinical pathology

    Mitochondrial-derived peptides as a novel intervention for obesity and cardiac diseases: bench evidence for potential bedside application.

    Kaorop W, Maneechote C, Kumfu S et al.

  14. 2022 OctBiochimica et biophysica acta. General subjects

    Humanin derivative, HNG, enhances neurotransmitter release.

    Ikegawa N, Kozuka A, Morita N et al.

  15. 2022 SepPeptides

    MOTS-c promotes muscle differentiation in vitro.

    García-Benlloch S, Revert-Ros F, Blesa JR et al.

  16. 2022 JanPharmacological research

    The mitochondrial-derived peptide MOTS-c relieves hyperglycemia and insulin resistance in gestational diabetes mellitus.

    Yin Y, Pan Y, He J et al.

  17. 2021 DecBiochimica et biophysica acta. General subjects

    Mitochondrial-derived peptides and exercise.

    Woodhead JST, Merry TL

  18. 2019Molecular & cellular oncology

    Nuclear transcriptional regulation by mitochondrial-encoded MOTS-c.

    Lee C